Preclinical Research Scientist for Neuroscience Drug Discovery

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Job Description

タケダの紹介

タケダでは常に患者さんを中心に考え、世界中の人々により健やかで輝かしい未来をお届けすることを目指してきました。そして従業員一人ひとりにそれぞれの能力と熱意に応じた成長の機会を提供することにも組んで取り組んでいます。私たちと一緒に、世界中の人々のいのちに貢献し、さらなる成長と活躍を目指しませんか。

タケダは業界を牽引するグローバルリーダーです。従業員は四つの優先順位（患者さん中心、社会との信頼関係構築、レピュテーションの向上、事業の発展）とタケダイズム（誠実＝公正・正直・不屈）のもと一致団結しています。タケダイズムは私たちの信念であり正しい方向へ導く羅針盤です。私たちは日々の業務においてタケダイズムを体現しています。

Takeda is unwavering in our commitment to patients. With the patient at the center of everything we do, we continue to innovate and drive changes that will better their lives - we’re looking for like-minded professionals to join us.

Takeda is a global industry leader –we are united by our four priorities (Patients, Trust, Reputation, and Business) and our shared values of Takeda-ism: Integrity, Fairness, Honesty, and Perseverance. Takeda-ism is more than just a word. It’s a belief and a mindset which guides our decisions, behaviors, and interactions. It’s how we strive to work and live, every day.

Objective / Purpose:

• Under the direction of the Associate Director, engages in preclinical drug discovery activities for diseases in Neuroscience field, especially neurodegenerative and rare neurological diseases.

• Participates in cross-functional drug discovery research projects and is represented as a biology expert to collaborate with colleagues in NS DDU as well as internal partners (GC, NCSP, DMPK, PS, TVS, CEI, TAU, etc.).

• Contributes to compound selection and data generation toward clinical candidates.

• Understands the drug discovery research to draw the research plan and ability to execute the accurate and reproducible experiments using skilled expertise and techniques with appropriate data analysis method.

• Develops or incorporates cutting-edge technique to discover novel drugs and to improve scientific expertise in Neuroscience DDU. Also engages with projects within Neurodgeneration Drug Discovery Laboratories by sharing one's insight and idea to support moving forward smoothly.

Accountabilities:

• Integrate and leverage science expertise to explore and select clinical candidates which accompanies scientific attractiveness, feasibility, fitness to the organizational strategy, and competitiveness.
• Establish the research plan and conduct it to obtain critical data for the decision making in the compound selection and project stage-ups.
• Assertively learning the innovative technologies and methods for the key experiments to understand the value of the target and asset.
• Contributes to scientific input as a biology core member or a functional leader of a project thorough one’s collaborative way of work with the key stake holders in Takeda such as PTS, Pharmasci, and Neuroscience TAU.
• Identifies, engages, and ensures the success of platform technologies in the neurodegenerative disease area for the target validation, mechanism of action,  and asset generation to provide the innovative acceleration of the asset generation.
• Keeps up to date with the latest scientific advancements (e.g., competitive situation, innovative technologies, and partnerships) and captures the future trends in the drug discovery in neurodegenerative disease area.
• Reports and consults with one’s supervisor about issues in a timely manner to enhance working culture where group members are empowered to commit to their job and demonstrate their ability in the daily work.
• Complies with a healthy and productive research environment through good learning and knowledge of operations in EHS, biosafety, animal handling etc.

Education & Competencies (Technical and Behavioral):

• High motivation to be a project leader in the NS research area.
• Experience in drug discovery research (in vitro or in vivo or both) for more than 5 years.
• Assertiveness to learn new area of disease and biology (in vitro or in vivo) for drug discovery including target validation, high-throughput screening, hit-to-lead optimization, and preclinical development to select clinical candidates through in vitro and in vivo data acquisition.
• Strong commitment to generate clinical candidates to achieve IND followed by positive ePOC.
• Collaborative way of work in the cross-functional collaborations and in one’s team.
• Understanding and compliant with the EHS, biosafety, ethics, and facility rules
• Resilient, honest, and transparent in one’s work to face scientific challenges in a timely manner.
• Language skills in Japanese and English enabling collaboration with global stakeholders.

• Experiences to be a leader in a team which had the diversified back ground and expertise.

• Expertise in biochemical such as ELISA, western blotting, flow cytometry, or immunohistochemical assays.
• Track record of accomplishment in research as evidenced by quality and quantity of publications/presentations and/or inventions and/or products and clinical candidates.

Takeda Compensation and Benefits Summary:

• Allowances: Commutation, Housing, Overtime Work etc.

• Salary Increase: Annually, Bonus Payment: Twice a year

• Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45

• Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)

• Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.

• Flexible Work Styles: Flextime, Telework

• Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

• It is possible the job scope may change at the company’s discretion.

• It is possible the department and workplace may change at the company’s discretion.

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