Director, Computational & Systems Biology - Early Clinical Development (ECD), GI and Inflammation Therapeutic Area Unit (GI²-TAU)

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Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

We have an exciting opportunity for a Director of Computational and Systems Biology to join our multi-disciplinary Early Clinical Development team. This leadership role focuses on supporting clinical development programs across multiple therapeutic areas, with a strategic emphasis on the Inflammatory Bowel Disease (IBD). The role will contribute to biomarker discovery, molecular differentiation, patient stratification, and data-driven decision-making across early- to late-stage programs, including life cycle management studies and new asset combinations.

We are looking for:

• A visionary leader to join the Computational & Systems Biology group within the Gastrointestinal & Inflammation Therapeutic Area Unit and play a pivotal role in our mission to deliver innovative therapies for patients.
• An expert in translational bioinformatics who will apply advanced computational biology, multi-omics integration, and AI/ML strategies to support clinical development, biomarker strategy, and mechanistic insights into treatment response and resistance.
• A strategic collaborator who will partner with clinical development, translational medicine, and discovery teams to define and execute biomarker strategies and analytical plans. This includes leading multiple clinical-stage projects, acting as a senior scientific consultant, and managing matrixed project teams.
• A proactive innovator to lead internal and external collaborations, develop cutting-edge analytical strategies, and support data-driven decision-making across the clinical development continuum.
• As Director, you will lead translational bioinformatics efforts aligned with the IBD strategy, ensuring scientific excellence and strategic execution across the portfolio.

ACCOUNTABILITIES

• Lead the strategic utilization of high-dimensional datasets, including multi-omics data from translational and clinical studies, to support the IBD strategy. This includes life cycle management study support, biomarker discovery, molecular differentiation, patient stratification, and drug combination strategies.
• Oversee data integration and network/pathway analysis to understand mechanisms of action, ensuring robust and insightful interpretations that guide clinical and translational strategies across the IBD portfolio.
• Direct the application of AI/ML tools and generative AI models for biomarker discovery, integrating findings with existing knowledge to advance translational medicine goals and enhance the impact of the IBD programs.
• Generate and test hypotheses to identify novel therapeutic targets and biomarkers, driving innovation and advancing our understanding of disease mechanisms in IBD and related immune-mediated conditions.
• Support and lead drug combination trials, leveraging bioinformatics insights to design and analyze studies that explore synergistic effects and optimize therapeutic outcomes within the IBD space.
• Lead and cultivate academic collaborations to expand scientific insight, validate translational hypotheses, and accelerate innovation in biomarker science and clinical development.
• Prepare and present comprehensive technical and scientific reports for both internal and external audiences, effectively communicating complex data and insights to stakeholders at all levels.
• Collaborate closely with project teams to influence experimental design, assay development, data generation, and analysis, ensuring alignment with strategic objectives and scientific rigor.
• Lead due diligence efforts for external opportunities as needed, providing expert evaluation and strategic recommendations to support business development initiatives aligned with the IBD strategy.
• Design and execute research projects independently, in collaboration with translational scientists, contributing to multiple projects as a senior scientific consultant and managing early-stage matrix project teams.
• Foster internal and external collaborations, developing innovative analytical strategies and supporting decision-making in early-stage clinical trials, with a focus on advancing the broader IBD portfolio.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

• PhD degree in a scientific discipline with 10+ years' experience , or
  MS with 16+ years' experience, or BS with 18+ years' experience 
• Strong background in multi-omics biomarker analysis, proteomics, single-cell and spatial transcriptomics or spatial high-content imaging data is preferred
• Additionaly, experience with genetics, pharmacogenomics and Real-world Data is preferable
• Knowledge of drug development and experience in a matrix team environment
• Experience with AI/ML, statistical analysis, including regression analysis, multivariate data analysis, and mixed-effects modeling is preferred
• Proficiency in Unix/Linux, command line interfaces, and scripting/programming languages (R, Python) for multi-omics analysis
• Recognized expertise in translational Multi-omics and genetics discovery and development as demonstrated by publications, regulatory submissions and/or national or international presentations
• Excellent understanding of drug development, regulatory processes, and clinical development
• Strong leadership abilities and proven ability to lead a team within a matrix organization as well as work independently
• Strong analytical, oral and written communication, problem solving and interpersonal skills

ADDITIONAL INFORMATION

• The position will be based in Cambridge, MA.This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$174,500.00 - $274,230.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

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